منابع مشابه
The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways.
The molecular clock is intimately linked to metabolic regulation, and brown adipose tissue plays a key role in energy homeostasis. However, whether the cell-intrinsic clock machinery participates in brown adipocyte development is unknown. Here, we show that Bmal1 (also known as ARNTL), the essential clock transcription activator, inhibits brown adipogenesis to adversely affect brown fat formati...
متن کاملTGF-β/Smad3 Signaling Regulates Brown Adipocyte Induction in White Adipose Tissue
Recent identification of active brown fat reserves in adult humans has re-stimulated interest in the role of brown adipocytes in energy homeostasis. In addition, there is accumulating evidence to support the concept of an alteration in energy balance through acquisition of brown fat features in traditional white fat depots. We recently described an important role played by the TGF-β/Smad3 signa...
متن کاملEBF2 determines and maintains brown adipocyte identity.
The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specific characteristics. Here, we show that early B cell factor-2 (Ebf2) regulates Pparγ binding activity to determine brown versus white adipocyte identity. The Ebf DNA-binding motif was highly enriched wit...
متن کاملNesfatin-1 promotes brown adipocyte phenotype
Nesfatin-1, an 82 amino acid gastric peptide, is involved in regulation of food uptake and in multiple metabolic activities. Whether nesfatin-1 modulates the differentiation and lipid metabolism of brown adipocytes remains unknown. In the present study, we found that nesfatin-1 mRNA and protein were detectable in isolated brown adipocytes and gradually decreased during differentiation (95% CI 0...
متن کاملAdrenergic regulation of brown adipocyte differentiation.
Introduction Brown and white fat-cells share a basic life pattern in developing from undifferentiated fibroblast-like precursors to becoming increasingly differentiated with time. Throughout the life of an organism, a pool of precursors remains available. It would seem that the number of white fatcells, at least, is not constant but is influenced by external factors, such as food supply, and so...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1989
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19890032